American Medical News for 11 Sep 2019
Paul S. Bernstein, M.D., Ph.D., spent more than a decade working with families at the John A. Moran Eye Center at the University of Utah on the hunt for the first gene known to cause a rare retinal... disease known as MacTel.
A research team investigating the promising anti-fibrotic effects of a drug version of the hormone, relaxin, has discovered that the receptor through which it mediates its therapeutic actions can... communicate and/or interact with other receptors in cells that contribute to fibrosis progression. This research may have implications for the design of clinical trials involving relaxin and its concomitant use with other drugs that act on these receptors.
(Credit: Shidlovski/Shutterstock) Cancer therapies often fail to work when tested in clinical trials. As a result, a startling 97 percent of drugs designed for specific cancer treatments do not... receive approval from the Food and Drug Administration. Now researchers say they may have figured out part of the reason why. In a new study out Wednesday in the journal Science Translational Medicine, scientists report many cancer drugs don't work the way their designers assumed they did. The dis
An observational study including 3.9 million cancer cases in seven high-income countries between 1995-2014 finds that survival of seven cancers is generally improving, although the overall level and... pace of improvement varies between countries and for each cancer type.
A new gene therapy turns glial cells -- abundant support cells in the brain -- into neurons, repairing damage that results from stroke and significantly improving motor function in mice.
Researchers have published a comprehensive list of the types and ratios of microbes that inhabit the healthy human gut.
The muscles in bats' wings are much cooler than the muscles in their core, a new study finds -- and this research could one day enhance our understanding of human muscle.
Researchers have shown that 10 different cancer drugs being given to about 1,000 human patients in clinical trials kill cancer in entirely different ways than previously thought.
Study finds that the diabetes drug metformin, known to promote brain repair, can also help restore cognitive function in adult mice but only in females and in a way that is dependent on the sex... hormone estradiol.
Scientists successfully conducted a first-in-human, FDA-approved Phase 1 clinical trial of an injectable hydrogel that aims to repair damage and restore cardiac function in heart failure patients who... previously suffered a heart attack. The trial is the first to test a hydrogel designed to repair cardiac tissue. It is also the first to test a hydrogel made from the natural scaffolding of cardiac muscle tissue.
In the face of obesity, the sex hormone progesterone that helps females get and stay pregnant appears to also put them at increased, early risk for cardiovascular disease, investigators report.
Using computational tools to investigate gene transcription networks in large collections of brain tissues, a scientific team has identified a gene that acts as a master regulator of schizophrenia... during early human brain development. The findings may lay the groundwork for future treatments for the highly complex neuropsychiatric disorder.
Researchers have developed biomaterial-based 'mimics' of heart tissues to measure patients' responses to an aortic valve replacement procedure, offering new insight into the ways that cardiac tissue... re-shapes itself post-surgery.
A new study found that adolescents who spend more than three hours a day on social media are more likely to report high levels of internalizing behaviors compared to adolescents who do not use social... media at all.
A team of marketing professors have studied the sensory impact of food and the evolution of healthy eating.
Scientists have identified a molecule that plays a pivotal role in determining the fate of cells under stress, much like a Roman emperor deciding the fate of gladiators in the coliseum. The findings... suggest a possible new approach for treatment of autoinflammatory and other diseases.
According to a new study, providing adolescents seeking birth control the ability to obtain a long-acting reversible contraceptive on the same day as their clinic visit could lead to significant cost... savings for insurance providers.
The frigid waters of the Antarctic may yield a treatment for a deadly disease that affects populations in some of the hottest places on earth. Current medications for that scourge -- malaria -- are... becoming less effective as drug resistance spreads. But researchers report that a peptide they isolated from an Antarctic sponge shows promise as a lead for new therapies.
CAR T-cell therapy, a rapidly emerging form of immunotherapy using patients' own cells to treat certain types of cancers, may be a viable treatment option for another life-threatening condition: heart... disease. Researchers at Penn Medicine used genetically modified T cells to target and remove activated fibroblasts that contribute to the development of cardiac fibrosis -- a scarring process found in most forms of heart disease that results in heart stiffness and decreased function of the heart.
Researchers have revealed an interaction between cortico-brainstem pathways during training-induced recovery in stroke model rats. The researchers demonstrated that the rapid compensatory recruitment... of the cortex-to-brainstem pathways occurred when other responsible motor circuits failed to function. This dynamic recruitment of the cortex-to-brainstem pathways is a key factor for functional recovery in intensive rehabilitation after stroke.
Researchers found that rabbit and mouse papillomaviruses could be transferred by blood to their respective hosts, raising the possibility that human papillomavirus (HPV) may also be transferable by... blood in humans.
Cold temperatures are not nearly as deadly as heat, with around 2% of all deaths in Australia related to heat, according to new research.
Should global government and philanthropic aid be invested in large public health deworming programs in low- and middle-income countries? Doctors know intestinal helminths can be unpleasant, but... should we be on a mission to 'deworm the world'? Will this really help people living in these poor areas, in terms of weight gain, increases in blood haemoglobin, and better attendance and performance at school?
Scientists have successfully tested new neuroprosthetic technology that combines robotic control with users' voluntary control, opening avenues in the new interdisciplinary field of shared control for... neuroprosthetic technologies.
The proportion of young people in Finland diagnosed with depression in specialized services is increasing, showed a study based on an extensive set of national data. An increasing number of... adolescents seek and get help, but the increase in service use burdens specialiszd services.