Have We Reached the End of Human Scale Physics?

Barenaked Ladies: It's All Been Done Every physics student has heard the story about how some prominent thinkers at the end of the 19th century were convinced that we had discovered all there was to know about physics. Only a few years later, all those physics pessimists were proven to be utterly, completely, unbelievably wrong as blossoming quantum mechanics and relativity theories combined to make up Modern Physics. Over the next century, lasers, transistors, GPS, MRI machines, PCs, cell phone...