Function restored in T cells from lupus patients by targetting lipid metabolism

Patients with the autoimmune disorder lupus erythematosus (SLE) exhibit multiple immune system defects. In this issue of the Journal of Clinical Investigation, Elizabeth Jury and colleagues at University College London reveal that T cells isolated from SLE patients have altered membrane-associated lipid profiles and exhibit increased lipid trafficking to the membrane and dysfunctional immune responses. Furthermore, normalization of lipid metabolism in isolated SLE T cells restored membrane lipid...