Blocking autophagy with malaria drug may help overcome resistance to BRAF drugs in melanoma

In many cases the root of resistance to BRAF inhibitors may lie in a never-before-seen autophagy mechanism induced by the BRAF inhibitors vermurafenib and dabrafenib, new research indicates. Half of melanoma patients with the BRAF mutation have a positive response to treatment with BRAF inhibitors, but nearly all of those patients develop resistance to the drugs and experience disease progression. Now, a new preclinical study found that in many cases the root of the resistance may lie in a never...