Suppressing tumors by pulling the plug on glycolysis

Cancer cells have long been known to have higher rates of the energy-generating metabolic pathway known as glycolysis. This enhanced glycolysis is thought to allow cancer cells to survive the oxygen-deficient conditions they experience in the center of solid tumors. Researchers reveal how damaged cells normally switch off glycolysis as they shut down and show that defects in this process may contribute to the early stages of tumor development.