Glycerol phenylbutyrate reduces hepatic encephalopathy events, ammonia levels compared to placebo in a phase 2 trial

Patients with hepatic encephalopathy experience neuropsychiatric symptoms that may range from mild confusion to coma. There is conflicting evidence on the link between elevated blood ammonia and hepatic encephalopathy. Poorly-absorbable disaccharides and antibiotics are currently used to treat encephalopathy and are generally believed to act by reducing ammonia production in the intestine. Phase 2 clinical results show the potential for Glycerol Phenylbutyrate (GPB) to reduce hepatic encephalopa...