New tool to confront lung cancer focuses on misregulation of two genes

Misregulation of two genes, sox2 and lkb1, drives squamous cell lung cancer in mice, researchers report. The discovery uncovers new treatment strategies, and provides a clinically relevant mouse model in which to test them. Only 15% of patients with squamous cell lung cancer -- the second most common lung cancer -- survive five years past diagnosis. Little is understood about how the deadly disease arises, preventing development of targeted therapies that could serve as a second line of defense ...