Autophagy is a new target for treatment of neuronal injury in the hippocampus of VD rats

(Neural Regeneration Research) Professor Bin Liu and co-workers from the Affiliated Hospital of Hebei United University, China intraperitoneally injected wortmannin into a rat model of vascular dementia. They found that wortmannin could inhibit hippocampal CA1 neuronal injury, elevate expression of the autophagy-related proteins beclin-1, cathepsin B and microtubule-associated protein 1 light chain 3. These results confirmed that autophagy is activated in the hippocampus of vascular dementia mod...