Normal cognition in patient without apolipoprotein E, risk factor for Alzheimer's

A 40-year-old California man exhibits normal cognitive function although he has no apolipoprotein E, which is believed to be important for brain function but a mutation of which is also a known risk factor for Alzheimer's disease. Researchers suggest this could mean that therapies to reduce apolipoprotein E in the central nervous system may one day help treat neurodegenerative disorders such as Alzheimer's disease.