Finding keys to glioblastoma therapeutic resistance

(University of California - San Diego) Researchers at the University of California, San Diego School of Medicine have found one of the keys to why certain glioblastomas -- the primary form of a deadly brain cancer -- are resistant to drug therapy. The answer lies not in the DNA sequence of the tumor, but in its epigenetic signature. These findings have been published online as a priority report in the journal Oncotarget.