San Francisco 49ers vs. St. Louis Rams: Spread Analysis and Pick Prediction

The San Francisco 49ers will try to beat the St. Louis Rams for the third straight time when they square off at the Edward Jones Dome on Monday Night Football. The 49ers swept last year’s two NFC West divisional matchups against the Rams, covering the spread as favorites both times, including a 35-11 victory at St. Louis in Week 4 as 3.5-point road chalk.   Point spread: The 49ers opened as four-point favorites; the total was 43.5 (line updates and matchup report).   Odds Shark computer pred...