Lack of transcription factor FoxO1 triggers pulmonary hypertension

Pulmonary hypertension is characterised by uncontrolled division of cells in the blood vessel walls. As a result, the vessel walls become increasingly thick. Scientists have discovered that transcription factor FoxO1 regulates the division of cells and plays a key role in the development of pulmonary hypertension. The researchers were able to cure pulmonary hypertension in rats by activating FoxO1.