Drugs behave as predicted in computer model of key protein, enabling cancer drug discovery

(Southern Methodist University) Drugs behaved as predicted in a computer-generated model of the key protein, P-glycoprotein, say researchers at Southern Methodist University, Dallas. The model allows pharmacological researchers to dock nearly any drug and see how it behaves in P-gp, a cellular protein linked to failure of chemotherapy. A dynamic mechanism that overcomes reliance on static images of P-gp's structure, the new model provides hope for finding drug-like compounds that inhibit P-gp fr...