Double enzyme hit may explain common cancer drug side effect

Many types of leukemia are caused by loss of enzymes such as Pten, which normally keeps cell growth in check, or conversely, the over-activation of enzymes that normally enhance cell proliferation, such as Shp2. Some anti-leukemia treatments work by inhibiting Shp2 or other enzymes involved in the same cellular systems, but researchers at University of California, San Diego School of Medicine have now found that mice lacking both of these enzymes -- Pten and Shp2 -- can't produce and sustain eno...