Finding Meaning in the Chaos of Protein-Protein Interactions

Proteins are the micromachines of the cell, catalyzing the reactions that make biology happen. Molecular reactants come in, and a distinct set of products emerges; in the process, energy is liberated, or cellular building blocks are shuttled along the assembly line. Spatial organization is a critical aspect of cellular reality - one that is rarely considered the central dogma (DNA --> RNA --> Proteins), whose elegant simplicity can overshadow biological realism. For example, a typica