Chronic HIV infection results in exhaustion of the immune system. Exhausted T cells display inhibitory proteins on their surface, and scientists hope to be able to restore immune function by interfering with the negative signals transmitted by such proteins. A new study suggests that one such strategy blocking the PD-1/PD-L1 pathway works, but only when the overall HIV load is low and regulatory T cells cooperate.
Chronic HIV infection results in exhaustion of the immune system. Exhausted T cells display inhibitory proteins on their surface, and scientists hope to be able to restore immune function by interfering with the negative signals transmitted by such proteins. A new study suggests that one such strategy blocking the PD-1/PD-L1 pathway works, but only when the overall HIV load is low and regulatory T cells cooperate.
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