New mouse-human modeling system enables study of disease development in vivo

A new mouse-human modeling system has been created that could be used to study neural crest development as well as the modeling of a variety of neural crest related diseases, including such cancers as melanoma and neurofibromatosis. Mouse-human chimeras would fill an important gap in disease research, as existing models do not accurately mimic key disease processes, including solid tumor initiation and progression, and are of little value for studying diseases with long latencies, such as Alzhei...