Nuclear export of opioid growth factor receptor is CRM1 dependent

(Society for Experimental Biology and Medicine) The opioid growth factor receptor (OGFr) interacts with a specific opioid growth factor ligand (OGF), chemically termed [Met5]-enkephalin, to maintain homeostasis in a wide variety of normal and abnormal cells and tissues. The mechanism underlying the function of OGFr requires that the receptor translocates to the nucleus. However, the mechanism of nuclear export of OGFr is unknown. Studies utilizing both endogenous OGFr, and exogenously expressed ...