Infradian oscillation of circadian genes in a mouse model of bipolar disorder

Molecular basis of changes in mood and mood-associated behaviors are unknown. Researchers in Japan have succeeded in predicting states of mood-change-like behavior by studying the gene expression patterns in the brain in a bipolar disorder mouse model. They found that expressions of circadian rhythm-associated genes concomitantly change with mood-change-like behaviors in these mice. The current results also provide a novel insight into the molecular basis of bipolar disorder in the brain.