How does obesity cause disease in organs distant from those where fat accumulates?

(European Society of Human Genetics) Many of the conditions related to obesity do not appear to affect the parts of the body where the excess fat accumulates, but rather to involve body systems that are remote from the fat accumulation. Now an international group of scientists has taken an important step towards understanding the links between obesity and the related, yet physically distant, diseases it causes, the annual conference of the European Society of Human Genetics will hear today.