Cancer researchers take on an old foe

(American Chemical Society) In the annals of cancer research, a protein known as KRas has become notorious. Part of a family of proteins implicated in 30 percent of cancers, KRas is considered a highly desirable but defiant drug target. Scientists have resuscitated efforts to crack its structure and find drugs to disable it. The cover story of Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society, reports on the latest efforts to fight KRas.