Krüppel-like factor 12 promotes colorectal cancer via early growth response protein 1

(Medical University of South Carolina) Medical University of South Carolina investigators report preclinical research showing that Krüppel-like factor 12 promotes colorectal cancer cell growth by activating early growth response protein 1, in the July 2016 issue of PLOS One. Data also reveal that levels of KLF12 and EGR1 correlate synergistically with a poor CRC prognosis. Results indicate that KLF12 plays an important role in CRC progression and provides a potential novel prognostic marker and...