Mechanism revealed for side effects of drug used in hematopoietic stem cell harvesting

Scientists have revealed the mechanism for side effects such as fever and bone pain caused by G-CSF, which is widely used for peripheral blood hematopoietic stem cell harvesting (PBSCH). This is an important method for hematopoietic stem cell transplantation (HSCT) used to treat hematological malignancies such as leukemia.