Metabolism drives growth and division of cancer cells

(University of Veterinary Medicine -- Vienna) Nobel Prize laureate Otto H. Warburg observed in the 1920s that tumor cells radically change their metabolism. This process, termed 'Warburg Effect,' was neglected until recently by cancer research, but latest results show ist fundamental importance for the development of aggressive tumors. Richard Moriggl from the VetmeduniVienna now published in Leukemia how the tumor promoter STAT5 integrates metabolic signals that contribute to oncogenic transfor...