Epigenetic alteration a promising new drug target for heroin use disorder

(The Mount Sinai Hospital / Mount Sinai School of Medicine) Heroin use is associated with excessive histone acetylation, an epigenetic process that regulates gene expression, and more years of drug use correlate with higher levels of hyperacetylation, according to research conducted at The Icahn School of Medicine at Mount Sinai and published in the journal Biological Psychiatry.