Multi-mechanism approach to treating neonatal hypoxic ischemia

Male sex is a risk factor for worse outcome following neonatal insult, including hypoxic ischemia. While N-acetylcysteine and hypothermia promote functional improvement in female rodents, similar improvement in males requires the addition of vitamin D, report investigators. Multi-mechanism approaches are needed to treat neonatal hypoxic ischemia, and those approaches appear to be different depending on sex.