Atoh1, a potential Achilles' heel of Sonic Hedgehog medulloblastoma

(Baylor College of Medicine) Tyrosine 78 in Atoh1 is phosphorylated exclusively in 'tumor-initiating cells' in sonic hedgehog medulloblastoma and reducing the levels of Atoh1 promotes tumor regression in mice and provides a potential future strategy for treating this type of tumor.