New links between genetic abnormality and brain function in Huntington's disease

(Mary Ann Liebert, Inc./Genetic Engineering News) While the gene mutation that causes Huntington's disease has been associated with changes in certain types of functional brain connectivity, a new study that examined connectivity across the whole brain has now identified alterations in functional connectivity in additional brain networks and has also shown significant associations between the extent of the degree of gene mutation and measures of motor and cognitive function.