Metastatic cancer cells modify bone remodeling with small RNA secretion in bone metastasis

(Tokyo Medical and Dental University) Prostate cancer frequently metastasizes and spreads to bone, causing severe pain, fractures, and other complications. The mechanisms that allow cancer cells to modify bone remodeling are incompletely understood. Researchers at Tokyo Medical and Dental University (TMDU) identified a microRNA, miR-940, that is abundant in exosomes secreted by prostate cancer cells and can trigger bone-forming lesions in mice. The findings indicate that microRNAs play a key rol...