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(Kazan Federal University) As the paper posits, there is currently no doubt that hyperpolarization of mitochondria and concomitant oxidative stress are associated with the development of serious pathologies, such as Parkinson's disease, Alzheimer's disease, autoimmune syndromes, some cancers, and other conditions. Hyperpolarized mitochondria have an elevated transmembrane potential because of the excess of H+ ions in the intermembrane space in comparison with the matrix (pH 8).
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