Lymphatic endothelial cells promote melanoma to spread

The lymph vessel endothelial cells play an active role in the spread of melanoma, according to the new study. The researchers found that growing human melanoma cells in co-cultures with human primary lymphatic endothelial cells revealed crosstalk of cancer cells with the tumor microenvironment leading to the increased invasive growth of melanoma cells and distant organ metastasis in a mouse tumour model.