Mechanism controlling multiple sclerosis risk identified

(Karolinska Institutet) While the DNA sequence remains the same throughout a person's life, the expression of the encoded genes may change with time and contribute to disease development in genetically predisposed individuals. Researchers at Karolinska Institutet have now discovered a new mechanism of a major risk gene for multiple sclerosis (MS) that triggers disease through epigenetic regulation. They also found a protective genetic variant that reduces the risk for MS. The study is published ...