Epigenetic reprogramming of human hearts found in congestive heart failure

(University of Alabama at Birmingham) Congestive heart failure is a terminal disease that affects nearly 6 million Americans. Yet its management is limited to symptomatic treatments because the causal mechanisms of congestive heart failure are not known. Researchers have now described an underlying mechanism that reprograms the hearts of patients with ischemic cardiomyopathy, a process that differs from patients with other forms of heart failure. This points the way toward future personalized ca...