STAT3 can be a therapeutic target for chronic active EBV infection, a fatal disorder

(Tokyo Medical and Dental University) Chronic active Epstein-Barr virus infection (CAEBV) is an inflammatory disorder with potential for tumor development. Here, unusual phosphorylation was observed on STAT3 in EBV-infected T- or NK-cells from patients with CAEBV. Tokyo Medical and Dental University(TMDU) researchers found that ruxolitinib, a drug that is currently used for treatment of myelofibrosis and polycythemia vera, could suppress the survival of these EBV-infected cells in a dose-depende...