Noninvasive light-sensitive recombinase for deep brain genetic manipulation

A research team presents a noninvasive light-sensitive photoactivatable recombinase suitable for genetic manipulation in vivo. The highly light-sensitive property of photoactivatable Flp recombinase will be ideal for controlling genetic manipulation in deep mouse brain regions by illumination with a noninvasive light-emitting diode. This easy-to-use optogenetic module will provide a side-effect free and expandable genetic manipulation tool for neuroscience research.