NSAID impairs immune response in heart failure, worsens heart and kidney damage

Non-steroidal anti-inflammatory drugs, or NSAIDs, are widely known as pain-killers and can relieve pain and inflammation. Researchers found that treatment with the NSAID carprofen alone triggered subtle low-grade inflammation in the heart and kidneys. The combination of carprofen pretreatment and heart attack magnified this impact by dysregulating the acute inflammatory response, amplifying inflammation and intensifying the cardiorenal syndrome.