Study finds melanoma brain metastases are immunosuppressive with treatment-resistant metabolism

(University of Texas M. D. Anderson Cancer Center) Melanoma tumors that have spread to the brain are equipped to thwart immunotherapies and targeted therapies that succeed against tumors growing in other sites. Researchers at the University of Texas MD Anderson Cancer Center report in Cancer Discovery that the heavy reliance of these tumors on a specific metabolic pathway presents a potentially new therapeutic against these lethal tumors.