Treatment to a T? Taking a 'BiTE' out of lung cancer

(Osaka University) An Osaka University-led research team assayed T cell cytotoxicity in tumor tissue in lung cancer, along with normal lung tissue and peripheral blood. They found associations of tumor T-cell cytotoxicity with smoking and cytokine levels. They also revealed that T-cell cytotoxicity in peripheral blood correlated with that in tumors, and also with the effectiveness of nivolumab in cancer immunotherapy. These findings provide a simple tool for predicting immune checkpoint inhibito...