Caffeine prevents PGE1-induced disturbances in respiratory neural control

Researchers propose PGE exerts adenosine-mediated effects on brainstem mechanisms of respiratory control, which may lead to destabilization of breathing in human infants undergoing treatment for congenital heart disease. Prostaglandin's effects could be mediated thorough microglia, and caffeine could be a convenient treatment to prevent respiratory instability in infants receiving PGE1 infusion.