Metabolic reprogramming of branched-chain amino acid facilitates drug resistance in lung cancer

(Chinese Academy of Sciences Headquarters) Research teams led by Dr. Ji Hongbin at the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences, Dr. Zhou Caicun at the Shanghai Pulmonary Hospital, Tongji University School of Medicine, and Dr. Li Cheng at the School of Life Sciences, Peking University, revealed the important role of epigenetic regulation-mediated metabolic reprogramming in lung cancer's capacity to resist molecular targeted therapy.