Using whole-genome sequencing for early identification and containment of AMR pathogens

A study published today examines the evolutionary and epidemiologic history of an epidemic strain of extensively drug-resistant tuberculosis (XDR-TB) -- called LAM4/KZN. This strain was first reported in a 2005 outbreak where it was associated with 90 percent mortality among predominantly HIV infected individuals, and has since become widespread throughout the province. A new study identifies key host, pathogen and environmental factors that facilitated the success of this XDR-TB strain.