High expression of apoptosis protein (Api-5) in chemoresistant triple-negative breast cancers

(Impact Journals LLC) 78 TNBC biopsies from patients with different responses to chemotherapy were analysed for API-5 expression before any treatment.Further studies on API-5 expression and inhibition were performed on patient-derived TNBC xenografts, one highly sensitive to chemotherapies and the other resistant to most tested drugs.Clinical analyses of the 78 TNBC biopsies revealed that API-5 was more markedly expressed in endothelial cells before any treatment among patients with chemoresista...