Cellular calpain proteases can cleave the enteroviral polyprotein

(University of Jyväskylä - Jyväskylän yliopisto) Enteroviruses can cause severe diseases such as encephalitis or myocarditis, and have been associated with chronic diseases such as type 1 diabetes. In her dissertation at the University of Jyvaskyla M.Sc Mira Laajala focuses on viral and host cell factors that promote the infection of enterovirus B species after cell entry. The research showed that in addition to enteroviral proteases, cellular calpain proteases can cleave the enteroviral pol...