MIV-711 not associated with pain reduction, but may reduce disease progression in osteoarthritis

(American College of Physicians) MIV-711, a novel selective cathepsin K inhibitor, was not more effective than placebo for reducing pain related to knee osteoarthritis. However, MIV-711 significantly reduced bone and cartilage progression. Findings from a randomized, placebo-controlled study are published in Annals of Internal Medicine.