Estrogen may facilitate the growth of liver metastases in non-sex-specific cancers

(McGill University Health Centre) A study led by Dr. Pnina Brodt shows that the liver immune microenvironment reacts to metastatic cells differently in male and that in female mice and estrogen can indirectly contribute to the growth of metastases. These findings provide a rationale for further exploration of the role of sex hormones in female cancer patients and the potential benefits of anti-estrogen drugs such as tamoxifen in the treatment of hormone-independent cancers that metastasize to th...