Interactions between cancer cells and fibroblasts promote metastasis

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) In order to colonize other organs and grow into metastases, tumor cells that detach from the parent tumor need to manipulate their new microenvironment and create a 'metastatic niche'. Scientists from the German Cancer Research Center and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine* have now discovered that some cancer cells stimulate connective tissue cells in their environment to release tr...