Newly emerged enterovirus-A71 C4 isolates may be more virulent than B5 in northern Vietnam

(Kanazawa University) Researchers from Kanazawa University have found a new sublineage of enterovirus A71 (EV-A71) C4 subgenotype with two possible recombinant strains during the 2015-16 outbreak of hand-foot-and-mouth disease in Hanoi, northern Vietnam. Further, they confirmed that the EV-A71-C4 subgenotype may be more virulent than the B5 clinically and experimentally with transgenic mouse model. This has helped elucidate the outbreak and may identify candidate viral strains for developing pol...