Chromosome 16p11.2 duplication impacts several different inhibitory neuron types that use GABA in brain areas that are dysfunctional in schizophrenia, including the prefrontal cortex, hippocampus, and amygdala. The chromosome 16p11.2 duplication also resulted in cognitive and social deficits that are symptomatic of schizophrenia.
Chromosome 16p11.2 duplication impacts several different inhibitory neuron types that use GABA in brain areas that are dysfunctional in schizophrenia, including the prefrontal cortex, hippocampus, and amygdala. The chromosome 16p11.2 duplication also resulted in cognitive and social deficits that are symptomatic of schizophrenia.
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