How upregulation of a single gene by SARS-CoV-2 can result in a cytokine storm

(IOS Press) The SARS-CoV-19 virus initially has a limited capability to invade, attacking only one intracellular genetic target, the aryl hydrocarbon receptors (AhRs). Yet it leads to widely diverse clinical symptoms, suggesting multiple pathogenic mechanisms. Writing in Restorative Neurology and Neuroscience, investigators describe how excessive activation of AhRs via the IDO1-kynurenine-AhR signaling pathway leads to "Systemic AhR Activation Syndrome" (SAAS). The authors also hypothesize that ...