Oncotarget: Clonality and antigen-specific responses shape prognostic effects

(Impact Journals LLC) Oncotarget Volume 11, Issue 27 reported that to delineate the complexity of anti-tumor T-cell responses, the author's utilized a computational method for de novo assembly of sequences from CDR3 regions of 369 high-grade serous ovarian cancers from TCGA, and then applied deep TCR-sequencing for analyses of paired tumor and peripheral blood specimens from an independent cohort of 99 ovarian cancer patients.